What Are the Best Mushrooms for Chronic Pain? - Xotic Mushrooms

12 Best Mushrooms for Chronic Pain

Chronic pain can be debilitating, affecting the quality of life for those who experience it. 

While there are various treatment options available, some individuals seek natural alternatives to manage their chronic pain. One such option gaining popularity is the use of mushrooms. 

In this article, we will explore the best mushrooms for chronic pain relief, their potential benefits, and how to incorporate them into your pain management routine..

Best Mushrooms for Chronic Pain

Medicinal mushrooms have been used for centuries in various cultures for their health benefits. This guide delves into 12 such mushrooms, exploring their potential in managing chronic pain and other health benefits.

1. Lion’s Mane

Lion's Mane for Chronic Pain

Lion’s Mane, scientifically known as Hericium erinaceus, is a mushroom revered for its brain health benefits. 

Traditionally used in Chinese medicine, it's known for its unique, shaggy appearance resembling a lion's mane.

Lion’s Mane is notable for its potential in nerve regeneration, which can be crucial in neuropathic pain management. It stimulates the production of Nerve Growth Factor (NGF), aiding in nerve repair and reducing pain.

Beyond pain relief, Lion's Mane is celebrated for enhancing cognitive functions and potentially slowing the progression of neurodegenerative diseases like Alzheimer's.

It can be consumed in various forms, including supplements, teas, and extracts. The dosage varies, but a general guideline is 500-1000 mg per day.

2. Cordyceps Mushrooms

Cordyceps Mushrooms for Chronic Pain

Cordyceps, particularly Cordyceps sinensis, has a history in traditional Tibetan and Chinese medicine. It's known for its unique growth on caterpillars in high mountain regions.

Cordyceps may help in reducing chronic pain due to its anti-inflammatory properties. It's also used in managing arthritis and other inflammatory conditions.

Known for boosting energy and endurance, Cordyceps is popular among athletes for improving performance and reducing fatigue.

Available in various forms like powders, capsules, and tinctures, it can be easily added to smoothies, teas, or meals.

3. Reishi Mushrooms

Reishi Mushrooms for Chronic Pain

Reishi mushroom, or Ganoderma lucidum, is known as the “mushroom of immortality” in Eastern medicine. It's recognized for its glossy, red-varnished appearance and woody texture.

Reishi's triterpenes and polysaccharides contribute to its anti-inflammatory properties, making it beneficial in pain management, especially in conditions like arthritis.

It also modulates the immune system, potentially benefiting those with autoimmune diseases, though it should be used cautiously.

Reishi mushrooms are typically consumed as teas, extracts, or supplements due to its bitter taste and tough texture.

4 Chaga

Chaga Mushrooms for Chronic Pain

Chaga (Inonotus obliquus) grows predominantly on birch trees in cold climates. It's known for its dark, charcoal-like exterior and rich antioxidant content.

Chaga's anti-inflammatory properties make it a candidate for managing chronic pain, particularly from inflammatory conditions.

Rich in antioxidants, Chaga supports overall health, potentially reducing oxidative stress linked to various chronic diseases.

Commonly consumed as a tea or supplement. Its mild flavor makes it a versatile addition to recipes.

5. King Trumpet

King Trumpet Mushrooms for Chronic Pain

King Trumpet, or Pleurotus eryngii, is the largest species in the oyster mushroom family. It's known for its meaty texture and culinary versatility.

Contains antioxidants and anti-inflammatory compounds that may help in reducing chronic pain, particularly related to inflammation.

Rich in vitamins, minerals, and fiber, it's a nutritious addition to any diet, supporting overall health.

Its robust texture makes it ideal for cooking, adding a meaty flavor to dishes like stir-fries, soups, and stews.

6. Turkey Tail

Turkey Tail for Chronic Pain

Turkey Tail (Trametes versicolor) is known for its striking, multi-colored fan shape. It's been used in traditional medicine for centuries.

Contains polysaccharopeptides, which may support the immune system and help in managing pain, especially in cancer patients.

Widely researched for its potential in cancer therapy, particularly in boosting the immune response during chemotherapy.

Commonly taken as a supplement or tea due to its tough texture.

7. Shiitake Mushrooms

Shiitake Mushrooms for Pain

Shiitake, or Lentinula edodes, is popular both as a gourmet ingredient and a medicinal mushroom. It's known for its rich, umami flavor.

Shiitake's compounds, like lentinan, may help in reducing inflammation and pain, particularly in conditions like arthritis.

Studies suggest shiitake can improve heart health by reducing bad cholesterol levels and improving circulation.

Versatile in cooking, it can be added to a variety of dishes, enhancing flavor and nutritional value.

8. Maitake

Maitake Mushrooms for Pain

Maitake, or Grifola frondosa, is known for its ruffled appearance and is used both in cooking and for medicinal purposes.

Its beta-glucans and other compounds may help in managing pain through anti-inflammatory effects and boosting immunity.

Maitake has been shown to help regulate blood sugar levels and improve cholesterol profiles.

Can be cooked or taken as a supplement. Its pleasant taste makes it a popular choice in culinary applications.

9. Psilocybin Mushrooms

Psilocybin Mushrooms for Pain

Psilocybin mushrooms, often referred to as "magic mushrooms," contain the psychoactive compound psilocybin. They have a history of use in spiritual and therapeutic contexts.

Emerging research suggests psilocybin may alter pain perception, potentially providing relief in chronic pain conditions.

Studies show promising results in treating depression and anxiety, conditions often associated with chronic pain.

Psilocybin is illegal in many countries and should be used only under legal and controlled settings, such as clinical trials. Due to legal and safety concerns, psilocybin should not be used without professional guidance and in a legal context.

10. Agaricus blazei

Agaricus blazei for Chronic Pain

Agaricus blazei, also known as the Brazilian mushroom, is renowned for its medicinal properties and has been used traditionally in Brazil and Japan.

This mushroom is known for its potential immune-boosting properties and may play a role in reducing inflammation, thereby aiding in pain management.

Rich in beta-glucans, Agaricus blazei is studied for its potential anticancer effects and overall health benefits.

Available in various forms like extracts, powders, and capsules, it can be incorporated into the diet as a supplement.

11. Tremella

Tremella Mushrooms for Pain

Tremella, known as the snow fungus, is prized in traditional Chinese medicine for its beauty-enhancing and medicinal properties.

Noted for its hydrating properties, Tremella is used in skincare and may also have anti-inflammatory effects beneficial for pain relief.

This jelly-like mushroom is rich in antioxidants and vitamins, supporting overall health and potentially aiding in pain management.

Tremella can be consumed in culinary dishes, particularly in Asian cuisine, or taken as a dietary supplement.

12. Phellinus linteus

Phellinus linteus

Phellinus linteus, commonly known as the black hoof mushroom, has a long history in Asian medicine, particularly in Korea and China.

This mushroom is recognized for its anti-inflammatory effects and is being studied for its potential in pain management and cancer treatment.

Phellinus linteus is believed to modulate the immune system, which could be beneficial in autoimmune conditions and chronic pain.

Typically consumed as an extract or in powdered form due to its tough, woody nature.

Best Ways to Take Medicinal Mushrooms for Chronic Pain

Incorporating medicinal mushrooms into your routine for chronic pain relief can be done in different ways. 

These include consuming mushrooms in their natural form, incorporating them into meals, preparing mushroom teas, or using mushroom extracts and supplements. 

It is advisable to consult with a healthcare professional or a knowledgeable practitioner before starting any new supplements or making significant changes to your diet.


What is the best mushroom for osteoarthritis?

While there is no specific mushroom that has been identified as the best for osteoarthritis, certain mushrooms like Hericium erinaceus have shown potential in reducing inflammation, which may help alleviate symptoms associated with osteoarthritis.

How do people cope with constant pain?

Coping with constant pain can be challenging, but there are several strategies that individuals can try. These may include seeking medical advice, exploring pain management techniques such as mindfulness and relaxation exercises, maintaining a healthy lifestyle, engaging in physical therapy, and considering complementary approaches like incorporating mushrooms for natural pain relief.

What is the best mushroom for depression?

While mushrooms are not a replacement for professional treatment of depression, some mushrooms like lion's mane have been studied for their potential in supporting cognitive function and improving mood

Which mushroom is best for joint health?

Mushrooms rich in anti-inflammatory properties, such as reishi and cordyceps, may potentially benefit joint health. These mushrooms may help reduce inflammation, which can contribute to joint pain and stiffness.

What is the best mushroom for arthritis and inflammation?

Mushrooms with anti-inflammatory properties, such as reishi and chaga, have shown potential for arthritis and inflammation relief. They may help reduce inflammation and alleviate symptoms associated with arthritis. However, individual responses can vary, and it is advisable to consult with a healthcare professional for personalized advice.

What is the best mushroom for autoimmune disease?

While mushrooms may offer potential benefits for immune system support, there is no specific mushroom identified as the best for autoimmune diseases. Medicinal mushrooms like reishi and cordyceps are often studied for their immune-modulating properties, but it is essential to consult with a healthcare professional to determine appropriate treatment options for autoimmune diseases.

What is the best mushroom for gut health?

Mushrooms with prebiotic properties, such as lion's mane and king trumpet, may contribute to gut health by supporting the growth of beneficial gut bacteria. These mushrooms can potentially help improve digestion and overall gut function. However, a balanced diet rich in fiber and diverse plant-based foods is essential for optimal gut health.

Should I take psychedelic mushrooms for pain relief?

Psychedelic mushrooms, such as psilocybin-containing mushrooms, are a different category from medicinal mushrooms discussed in this article. Psychedelic mushrooms are not recommended or approved for pain relief purposes. It is important to adhere to legal and medical guidelines regarding the use of any substances and consult with a healthcare professional for appropriate pain management options.


Functional mushrooms offer a diverse range of health benefits, particularly in managing chronic pain. From Lion’s Mane to Psilocybin, each mushroom presents unique properties that can aid in pain relief, immune support, and overall well-being. 

While the potential of these mushrooms is promising, it's crucial to approach their use with care, considering individual health conditions and consulting healthcare professionals. 

As research continues to evolve, these natural remedies stand as a testament to the intricate connection between nature and human health.

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